منابع مشابه
Therapeutic approaches for corneal neovascularization
Angiogenesis refers to new blood vessels that originate from pre-existing vascular structures. Corneal neovascularization which can lead to compromised visual acuity occurs in a wide variety of corneal pathologies. A large subset of measures has been advocated to prevent and/or treat corneal neovascularization with varying degrees of success. These approaches include topical corticosteroid admi...
متن کاملCorneal Neovascularization: A Translational Perspective
Corneal neovascularization (CNV) results from the growth of new vessels from the limbal vasculature into the normally avascular cornea. As the second cause of severe visual impairment worldwide, it represents a major clinical problem. This occurs because CNV often leads to corneal opacification, thus reducing visual acuity. CNV is a well characterized and complex process, which includes differe...
متن کاملCorneal neovascularization and biological therapy
Corneal avascularity is necessary for the preservation of optimal vision. The cornea maintains a dynamic balance between pro- and antiangiogenic factors that allows it to remain avascular under normal homeostatic conditions. Corneal neovascularization (NV) is a condition that can develop in response to inflammation, hypoxia, trauma, or limbal stem cell deficiency and it is a significant cause o...
متن کاملThalidomide prevents Corneal Angiogenesis in an Alkali Burn model of Rabbit Corneal Neovascularization
Objectives: To determine if Thalidomide has a similar effect in an alkali burn model of corneal neovascularization, we evaluated the effect of Thalidomide on corneal angiogenesis after alkali corneal burns in rabbits. Methods: Twelve rabbits received alkali burns to one cornea. Post injury, four rabbits received oral Thalidomide, 200 mg/kg/day and eight rabbits received placebo (powdered sugar)...
متن کاملThalidomide prevents donor corneal graft neovascularization in an alkali burn model of corneal angiogenesis.
OBJECTIVE Thalidomide is a potent inhibitor of angiogenesis. We evaluated the effects of Thalidomide on corneal angiogenesis and on tissue survival of grafts in rabbit eyes with pre-existing neovascularization secondary to alkali burn. METHODS Sixteen rabbits received alkali burns to one cornea. One month post-injury, assessments of corneal neovascularization were performed followed by cornea...
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ژورنال
عنوان ژورنال: Oman Journal of Ophthalmology
سال: 2013
ISSN: 0974-620X
DOI: 10.4103/0974-620x.122283